Endocrine Abstracts

Glucocorticoids (Gc) are potent anti-inflammatory steroids which mediate their effects by binding the glucocorticoid receptor (GR). Following ligand binding, GR initiates rapid ‘non-genomic’ kinase signals in the cytoplasm, then translocates into the nucleus to mediate ‘genomic’ effects by binding DNA directly or tethering to other DNA bound transcription factors to modulate target gene expression. Little is known about how rapidly induced cytoplasm derived...